Effect of IFN-α on CC14-induced fibrosis of the liver and immune status in mice of different age

被引：1
|
作者：
Filimonov, PN [1 ]
Sukhenko, TG
Gavrilova, NI
Shkurupii, VA
机构：
[1] Novosibirsk State Med Acad, Novosibirsk, Russia
[2] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Novosibirsk, Russia
[3] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 139卷 / 03期
关键词：
CCl4; fibrosis; age; IFN-alpha;
D O I：
10.1007/s10517-005-0284-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In young, adult, and old mice fibrosis was induced by administration of CCl4 and treated with IFN-alpha. Liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. Minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.
引用
收藏
页码：324 / 327
页数：4
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