Rh(III)-Catalyzed Decarboxylative ortho-Heteroarylation of Aromatic Carboxylic Acids by Using the Carboxylic Acid as a Traceless Directing Group

被引：103
|
作者：
Qin, Xurong [1 ,2 ,3 ]
Sun, Denan [1 ,2 ]
You, Qiulin [1 ,2 ]
Cheng, Yangyang [1 ,2 ]
Lan, Jingbo [1 ,2 ]
You, Jingsong [1 ,2 ]
机构：
[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China
[2] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, Chengdu 610064, Peoples R China
[3] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 07期
关键词：
C-H FUNCTIONALIZATION; DIRECT ARYLATION; BENZOIC-ACIDS; CONVENIENT SYNTHESIS; SIMPLE ARENES; RHODIUM; ARYL; DERIVATIVES; THIOPHENES; AMIDATION;
D O I：
10.1021/acs.orglett.5b00532
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Highly selective decarboxylative ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh(III)-catalyzed two-fold C-H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.
引用
收藏
页码：1762 / 1765
页数：4
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