Prodrug approach in new drug design and development

被引：0
|
作者：
Singh, G [1 ]
Wadhwa, LK [1 ]
Sharma, PD [1 ]
机构：
[1] PANJAB UNIV, INST PHARMACEUT SCI, CHANDIGARH 160014, INDIA
来源：
JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH | 1996年 / 55卷 / 07期
关键词：
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The prodrug approach involves chemical modification of drug molecules tp alter their physicochemical properties, temporarily, aiming at increasing their usefulness and reducing their toxic side effects. Prodrug research has undergone considerable expansion during the last few years and at present, this approach is used as an integral part of basic drug design and development. The present paper discusses the prodrug concept and describes various prodrug-type derivatives introduced in the world market as new chemical entities (NCEs) during 1983-1994.
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页码：497 / 510
页数：14
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