Anti-inflammatory Principles from Cordyceps sinensis

被引：95

作者：

Yang, Mei-Lin ^{[1
]}

Kuo, Ping-Chung ^{[2
]}

Hwang, Tsong-Long ^{[3
]}

Wu, Tian-Shung ^{[1
,4
,5
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Tao Yuan 333, Taiwan

[4] China Med Univ, Dept Pharm, Taichung 401, Taiwan

[5] China Med Univ, Chinese Med Res & Dev Ctr, Taichung 401, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 09期

关键词：

INHIBITION; MILITARIS; MYCELIA; EXTRACT; GROWTH; CELLS;

D O I：

10.1021/np100902f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-beta-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.45 +/- 0.15 and 1.68 +/- 0.32 mu M, respectively.

引用

页码：1996 / 2000

页数：5

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