Role of Actin Cytoskeleton in the Regulation of Epithelial Cutaneous Stem Cells

被引：11

作者：

Yang, Gink N. ^{[1
]}

Kopecki, Zlatko ^{[1
]}

Cowin, Allison J. ^{[1
]}

机构：

[1] Univ S Australia, Future Ind Inst, M1-08E,M Bldg,Mawson Lakes Campus, Adelaide, SA 5095, Australia

来源：

STEM CELLS AND DEVELOPMENT | 2016年 / 25卷 / 10期

关键词：

INTEGRIN-LINKED KINASE; HAIR FOLLICLE MORPHOGENESIS; EPIDERMAL STEM; FLIGHTLESS-I; WOUND REPAIR; EPIDERMOLYSIS-BULLOSA; SELF-RENEWAL; RHO GTPASES; SKIN; MIGRATION;

D O I：

10.1089/scd.2016.0051

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cutaneous stem cells (CSCs) orchestrate the homeostasis and regeneration of mammalian skin. Epithelial CSCs have been isolated and characterized from the skin and hold great potential for tissue engineering and clinical applications. The actin cytoskeleton is known to regulate cell adhesion and motility through its intricate participation in signal transduction and structural modifications. The dynamics of actin cytoskeleton can directly influence CSCs behaviors including tissue morphogenesis, homeostasis, niche maintenance, activation, and wound repair. Various regulators of the actin cytoskeleton including kinases, actin-remodeling proteins, paracrine signals, and micro-RNAs collaborate and contribute to epithelial CSC proliferation, adhesion, and differentiation. This review brings together the latest mechanistic insights into how the actin cytoskeleton participates in the regulation of epithelial CSCs during development, homeostasis, and wound repair.

引用

页码：749 / 759

页数：11

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