Neoadjuvant immunotherapy for muscle invasive urothelial bladder carcinoma: will it change current standards?

被引:9
|
作者
Renner, Alex [2 ]
Burotto, Mauricio [2 ]
Valdes, Jose Miguel [3 ]
Roman, Juan Carlos [1 ]
Walton-Diaz, Annerleim [1 ]
机构
[1] Univ Chile, Unofus SpA, Intituto Nacl Canc, Prof Zanartu 1010, Santiago, Chile
[2] Univ Los Andes, Bradford Hill Clin Res Ctr, Santiago, Chile
[3] Univ Los Andes, Santiago, Chile
关键词
bladder cancer; immune checkpoint inhibitor; immunotherapy; muscle invasive; neoadjuvant; SINGLE-ARM; CHEMOTHERAPY; MULTICENTER; CANCER; CISPLATIN;
D O I
10.1177/17562872211029779
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Immunotherapy, in the form of immune checkpoint inhibitors (ICI), has shown activity in metastatic urothelial bladder carcinoma, resulting in the approval of several ICI agents in the first- and second-line settings. This has led to an increased interest in studying their efficacy in the neoadjuvant setting for muscle invasive disease - an area of significant unmet need. This non-systematic review will look at the evidence supporting the use of ICI in the neoadjuvant setting for this tumor, results of early-phase studies, ongoing trials, and possible future applications for these drugs.
引用
收藏
页数:7
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