Body Mass Index and Breast Size in Women: Same or Different Genes?

被引：33
|
作者：
Wade, Tracey D. [1 ]
Zhu, Gu [2 ]
Martin, Nicholas G. [2 ]
机构：
[1] Flinders Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia
[2] Univ Queensland, Queensland Inst Med Res, Brisbane, Qld 4072, Australia
来源：
TWIN RESEARCH AND HUMAN GENETICS | 2010年 / 13卷 / 05期
基金：
英国医学研究理事会;
关键词：
breast size; body mass index; heritability; bivariate Cholesky; TO-HIP RATIO; AUSTRALIAN TWIN COHORT; CANCER RISK; EATING-DISORDERS; WEIGHT; HEALTH;
D O I：
10.1375/twin.13.5.450
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The objective of the current study was to investigate the heritability of breast size and the degree to which this heritability is shared with BMI. In a sample of 1010 females twins (mean age 35 years; SD = 2.1; range 28-40), self-report data pertaining to bra cup size and body mass index (BMI) was collected in the context of self-report data and an interview relating to disordered eating respectively. In a sample of 348 complete twin pairs who completed data collection (226 MZ pairs and 122 DZ pairs and 360 incomplete pairs (170 MZ and 190 DZ)), we found that the heritability of bra cup size was 56%. Of this genetic variance, one third is in common with genes influencing body mass index, and two thirds (41% of total variance) is unique to breast size, with some directional evidence of non-additive genetic variation. The implications of these findings with respect to previous research linking breast size with reproductive potential are discussed.
引用
收藏
页码：450 / 454
页数：5
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