Immunotherapy as a treatment strategy in advanced stage and recurrent endometrial cancer: review of current phase III immunotherapy clinical trials

被引：8
|
作者：
Eskander, Ramez N. [1 ]
Powell, Matthew A. [2 ]
机构：
[1] Univ Calif San Diego, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA
[2] Washington Univ, Sch Med, Dept Obstet & Gynecol, Div Gynecol Oncol, St Louis, MO 63110 USA
来源：
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2021年 / 13卷
关键词：
antiangiogenic therapy; chemotherapy; combination therapy; endometrial cancer; immune checkpoint inhibition; immunotherapy; tumor mutational burden; CARBOPLATIN; PACLITAXEL;
D O I：
10.1177/17588359211001199
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The treatment of advanced stage, metastatic or recurrent endometrial cancer remains a clinically difficult scenario. Although combination carboplatin and paclitaxel is an effective standard-of-care regimen, alternate strategies have shown promise, particularly in biomarker select populations. In an effort to improve oncologic outcomes, investigators are exploring novel immunotherapy combinations. In this review, we discuss the clinical rationale and design of current phase III immuno-oncology clinical trials in patients with advanced stage or recurrent endometrial cancer.
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页数：9
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