Biomarkers for the Clinical Diagnosis of Alzheimer's Disease: Metabolomics Analysis of Brain Tissue and Blood

被引：20

作者：

Wang, Yang-Yang ^{[1
]}

Sun, Yan-Ping ^{[1
]}

Luo, Yu-Meng ^{[1
]}

Peng, Dong-Hui ^{[1
]}

Li, Xiao ^{[1
]}

Yang, Bing-You ^{[1
]}

Wang, Qiu-Hong ^{[2
]}

Kuang, Hai-Xue ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, Minist Educ, Harbin, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

alzheimer's disease; candidate diagnosis biomarker; metabolomics; brain and blood samples; clinical screening; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; DEMENTIA ASSESSMENT SCALE; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; CEREBROSPINAL-FLUID; METABOLITE MARKERS; BETA DEPOSITION; SENILE PLAQUES; RISK;

D O I：

10.3389/fphar.2021.700587

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With an increase in aging populations worldwide, age-related diseases such as Alzheimer's disease (AD) have become a global concern. At present, a cure for neurodegenerative disease is lacking. There is an urgent need for a biomarker that can facilitate the diagnosis, classification, prognosis, and treatment response of AD. The recent emergence of highly sensitive mass-spectrometry platforms and high-throughput technology can be employed to discover and catalog vast datasets of small metabolites, which respond to changed status in the body. Metabolomics analysis provides hope for a better understanding of AD as well as the subsequent identification and analysis of metabolites. Here, we review the state-of-the-art emerging candidate biomarkers for AD.

引用

页数：14

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