Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging

被引：44
|
作者：
Ekanger, Levi A. [1 ]
Allen, Matthew J. [1 ]
机构：
[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA
来源：
METALLOMICS | 2015年 / 7卷 / 03期
基金：
美国国家卫生研究院;
关键词：
MRI CONTRAST AGENTS; SATURATION-TRANSFER CEST; IN-VIVO; HIGH-RELAXIVITY; WATER-EXCHANGE; RATIOMETRIC PROCEDURE; RELAXATION AGENTS; GD(III) COMPLEX; PARACEST AGENTS; FIELD-STRENGTH;
D O I：
10.1039/c4mt00289j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In magnetic resonance imaging, contrast agents are molecules that increase the contrast-to-noise ratio of non-invasively acquired images. The information gained from magnetic resonance imaging can be increased using responsive contrast agents that undergo chemical changes, and consequently changes to contrast enhancement, for example in response to specific biomarkers that are indicative of diseases. A major limitation with modern responsive contrast agents is concentration-dependence that requires the concentration of contrast agent to be known: an extremely challenging task in vivo. Here, we review advances in several strategies aimed at overcoming the concentration-dependent nature of responsive contrast agents.
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页码：405 / 421
页数：17
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