Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies

被引:92
|
作者
Talac, R
Friedman, JA
Moore, MJ
Lu, L
Jabbari, E
Windebank, AJ
Currier, BL
Yaszemski, MJ
机构
[1] Mayo Clin & Mayo Grad Sch Med, Dept Orthopaed Surg, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Grad Sch Med, Dept Biomed Engn, Rochester, MN 55905 USA
关键词
spinal cord injury; tissue engineering; animal models;
D O I
10.1016/S0142-9612(03)00497-6
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCL This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations. technical and animal care considerations, and data analysis methods. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1505 / 1510
页数:6
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