Koshikamide A2, a cytotoxic linear undecapeptide isolated from a marine sponge of Theonella sp.

被引：13

作者：

Araki, T ^{[1
]}

Matsunaga, S ^{[1
]}

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 07期

关键词：

cytotoxic metabolite; marine sponge; undecapeptide;

D O I：

10.1271/bbb.69.1318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Koshikamide A(2) (2) was isolated as a cytotoxic metabolite from a marine sponge of Theonella sp. Its structure was elucidated to be a linear undecapeptide by spectroscopic and chemical methods, together with enzymatic conversion to known koshikamide A(1) (1). The new peptide moderately inhibited the growth of P388 murine leukemia cells.

引用

页码：1318 / 1322

页数：5

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