Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

被引：92

作者：

Patil, Chetan A. ^{[1
]}

Bosschaart, Nienke ^{[2
,3
]}

Keller, Matthew D. ^{[1
]}

van Leeuwen, Ton G. ^{[2
,3
]}

Mahadevan-Jansen, Anita ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA

[2] Univ Twente, Fac Sci & Technol, Biophys Engn Grp, NL-7500 AE Enschede, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Ctr Laser, NL-1100 DD Amsterdam, Netherlands

来源：

OPTICS LETTERS | 2008年 / 33卷 / 10期

关键词：

D O I：

10.1364/OL.33.001135

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab. (C) 2008 Optical Society of America.

引用

页码：1135 / 1137

页数：3

共 50 条

[1] Improvement of tissue analysis and classification using Optical Coherence Tomography combined with Raman spectroscopy
Liu, Chih-Hao
Qi, Ji
Lu, Jing
Wang, Shang
Wu, Chen
Shih, Wei-Chuan
Larin, Kirill V.
DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS XI, 2014, 8942
[2] Improvement of tissue analysis and classification using optical coherence tomography combined with Raman spectroscopy
Liu, Chih-Hao
Qi, Ji
Lu, Jing
Wang, Shang
Wu, Chen
Shih, Wei-Chuan
Larin, Kirill V.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 2015, 8 (04)
[3] Depth-sensitive Raman spectroscopy combined with optical coherence tomography for layered tissue analysis
Khan, Khan M.
Krishna, Hemant
Majumder, Shovan K.
Rao, K. Divakar
Gupta, Pradeep K.
JOURNAL OF BIOPHOTONICS, 2014, 7 (1-2) : 77 - 85
[4] Combined Information from Raman Spectroscopy and Optical Coherence Tomography for Enhanced Diagnostic Accuracy in Tissue Discrimination
Ashok, Praveen C.
Praveen, Bavishna B.
Bellini, Nicola
Riches, Andrew
Dholakia, Kishan
Herrington, C. Simon
BIOMEDICAL VIBRATIONAL SPECTROSCOPY VI: ADVANCES IN RESEARCH AND INDUSTRY, 2014, 8939
[5] Combined optical coherence tomography and fluorescence spectroscopy for characterization of tissues
Barton, JK
Hariri, L
Tumlinson, A
2003 IEEE LEOS ANNUAL MEETING CONFERENCE PROCEEDINGS, VOLS 1 AND 2, 2003, : 458 - 459
[6] COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY FOR THE DETECTION OF SKIN CANCERS
Patil, Chetan
Krishnamoorthi, Harish
Mackanos, Mark
van Leeuwen, Ton
Ellis, Darrel
Mahadevan-Jansen, Anita
LASERS IN SURGERY AND MEDICINE, 2010, : 16 - 17
[7] Optical coherence tomography and Raman spectroscopy of the retina
Evans, Julia W.
Zawadzki, Robert J.
Liu, Rui
Chan, James W.
Lane, Stephen M.
Werner, John S.
MULTIMODAL BIOMEDICAL IMAGING IV, 2009, 7171
[8] A Clinical Instrument for Combined Raman Spectroscopy-Optical Coherence Tomography of Skin Cancers
Patil, Chetan A.
Kirshnamoorthi, Harish
Ellis, Darrel L.
van Leeuwen, Ton G.
Mahadevan-Jansen, Anita
LASERS IN SURGERY AND MEDICINE, 2011, 43 (02) : 143 - 151
[9] Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography
Patil, Chetan A.
Kalkman, Jeroen
Faber, Dirk J.
Nyman, Jeffry S.
van Leeuwen, Ton G.
Mahadevan-Jansen, Anita
JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (01)
[10] Optical coherence tomography device for paper characterization
Alarousu, E
Krehut, L
Myllyla, R
Hast, J
SARATOV FALL MEETING 2003: COHERENT OPTICS OF ORDERED AND RANDOM MEDIA IV, 2003, 5475 : 48 - 55

← 1 2 3 4 5 →