Novel HPPD inhibitors: triketone 2H-benzo[b][1,4]oxazin-3(4H)-one analogs

被引：26

作者：

Li, Hua-Bin ^{[1
,2
]}

Li, Lei ^{[1
]}

Li, Jun-Xian ^{[1
]}

Han, Ting-Feng ^{[1
]}

He, Jing-Li ^{[1
]}

Zhu, You-Quan ^{[1
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin, Peoples R China

[2] Nankai Univ, Coll Chem, Natl Pesticide Engn Res Ctr Tianjin, Tianjin, Peoples R China

来源：

PEST MANAGEMENT SCIENCE | 2018年 / 74卷 / 03期

基金：

中国国家自然科学基金;

关键词：

HPPD; herbicidal activity; benzoxazinone; synthesis; triketone; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; HERBICIDAL ACTIVITY;

D O I：

10.1002/ps.4739

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

BACKGROUND: Herbicides that inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) are very important for grass weed control. In order to discover novel HPPD herbicides, a series of triketone 2H-benzo[b] oxazin-3(4H)-one analogs was designed and synthesized. RESULTS: In comparison with the commercial triketone HPPD herbicide mesotrione (IC50 = 0.252 M), some of these new triketone analogs displayed excellent HPPD inhibitory potency in vitro, for example B39 (IC50 = 0.172 M) and B41 (IC50 = 0.156 M). In addition, some of these compounds exhibited pre- and post-emergence herbicidal activity similar to mesotrione when applied at 375 g/ha. CONCLUSION: Many of the title compounds described in this paper could be important lead structures for the further development of novel HPPD herbicides. (C) 2017 Society of Chemical Industry

引用

页码：579 / 589

页数：11

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