Identification of Minimal Neuronal Networks Involved in Flexor-Extensor Alternation in the Mammalian Spinal Cord

被引:72
|
作者
Talpalar, Adolfo E. [1 ]
Endo, Toshiaki [1 ]
Low, Peter [1 ]
Borgius, Lotta [1 ]
Hagglund, Martin [1 ]
Dougherty, Kimberly J. [1 ]
Ryge, Jesper [1 ]
Hnasko, Thomas S. [2 ]
Kiehn, Ole [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, Mammalian Locomotor Lab, S-17177 Stockholm, Sweden
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA
基金
英国医学研究理事会;
关键词
RECIPROCAL IA INHIBITION; MOTOR AXON COLLATERALS; PATTERN GENERATION; RHYTHMIC ACTIVITY; NEONATAL MOUSE; IN-VITRO; VOLTAGE OSCILLATIONS; RECURRENT INHIBITION; LOCOMOTOR CIRCUITS; FICTIVE LOCOMOTION;
D O I
10.1016/j.neuron.2011.07.011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neural networks in the spinal cord control two basic features of locomotor movements: rhythm generation and pattern generation. Rhythm generation is generally considered to be dependent on glutamatergic excitatory neurons. Pattern generation involves neural circuits controlling left-right alternation, which has been described in great detail, and flexor-extensor alternation, which remains poorly understood. Here, we use a mouse model in which glutamatergic neurotransmission has been ablated in the locomotor region of the spinal cord. The isolated in vitro spinal cord from these mice produces locomotor-like activity-when stimulated with neuroactive substances-with prominent flexor-extensor alternation. Under these conditions, unlike in control mice, networks of inhibitory interneurons generate the rhythmic activity. In the absence of glutamatergic synaptic transmission, the flexor-extensor alternation appears to be generated by la inhibitory interneurons, which mediate reciprocal inhibition from muscle proprioceptors to antagonist motor neurons. Our study defines a minimal inhibitory network that is needed to produce flexor-extensor alternation during locomotion.
引用
收藏
页码:1071 / 1084
页数:14
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