Mechanisms mediating antigenic variation in Trypanosoma brucei

被引:4
|
作者
Rudenko, G [1 ]
机构
[1] Univ Oxford, Dept Zool, Welcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3PS, England
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1999年 / 94卷 / 02期
基金
英国惠康基金;
关键词
antigenic variation; Trypanosoma brucei; variant surface glycoprotein (VSG); VSG expression site;
D O I
10.1590/S0074-02761999000200021
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VSG expression sites, or DNA rearrangement events slotting previously, inactive VSG genes into an active VSG expression site. In recent years, considerable progress has been made in techniques allowing us to genetically, modify, infective bloodstream form trypanosomes. This is allowing us to reengineer VSG expression sites, and look at the effect on the mechanisms subsequently used for antigenic variation. We can now begin a dissection of a highly, complicated survival strategy, mediated by, many different mechanisms operating simultaneously.
引用
收藏
页码:235 / 237
页数:3
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