A game theoretical approach to the classification problem in gene expression data analysis

被引：27
|
作者：
Fragnelli, Vito [1 ]
Moretti, Stefano [1 ]
机构：
[1] Natl Inst Canc Res, Unit Mol Epidemiol, I-16132 Genoa, Italy
来源：
COMPUTERS & MATHEMATICS WITH APPLICATIONS | 2008年 / 55卷 / 05期
关键词：
gene expression analysis; cooperative game; classification problem; shapley value; interaction index;
D O I：
10.1016/j.camwa.2006.12.088
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
Microarray technology allows for the evaluation of the level of expression of thousands of genes in a sample of cells under a given condition. In this paper, we introduce a methodology based on cooperative Game Theory for the selection of groups of genes with high power in classifying samples, according to gene expression patterns. The connection between microarray games and classification games is discussed and the use of the Shapley value to measure the power of genes for classification is motivated on particular instances and compared to the interaction index. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：950 / 959
页数：10
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