Oxidative and hydrolytic DNA cleavage by Cu(II) complexes of salicylidene tyrosine schiff base and 1,10 phenanthroline/bipyridine

被引：49

作者：

Reddy, Pulimamidi Rabindra ^{[1
]}

Shilpa, Addla ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

POLYHEDRON | 2011年 / 30卷 / 04期

关键词：

Tyrosine schiff base complexes; DNA binding; Oxidative DNA cleavage; Hydrolytic DNA cleavage; Kinetics; CRYSTAL-STRUCTURE; ETHIDIUM-BROMIDE; COPPER(II) COMPLEXES; BIOLOGICAL-ACTIVITY; TERNARY COMPLEXES; METAL-COMPLEXES; IMAGING AGENTS; NUCLEIC-ACIDS; BINDING; FLUORESCENCE;

D O I：

10.1016/j.poly.2010.11.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ternary Cu(II) complexes [Cu(II)(saltyr)(B)] (1,2), (saltyr = salicylidene tyrosine, B = 1,10 phenanthroline (1) or 2,2' bipyridine (2)) were synthesized and characterized by various techniques. The complexes exhibit square pyramidal (CuN3O2) geometry. CT-DNA binding studies revealed that the complexes show good binding propensity (K-b = 3.47 x 10(4) M-1 and 3.01 x 10(4) M-1 for 1 and 2, respectively). The role of these complexes in the oxidative and hydrolytic DNA cleavage was studied. The catalytic ability of 1 and 2 follows the order: 1 > 2. The rate constants for the hydrolysis of phosphodiester bond were determined as 2.80 h(-1) and 2.11 h(-1) for 1 and 2, respectively. It amounts to (0.58-0.77) x 10(8) fold rate enhancement compared to non-catalyzed DNA cleavage, which is significant. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：565 / 572

页数：8

共 50 条

[21] Synthesis, structure, magnetic properties and DNA cleavage of binuclear Cu(II) Schiff-base complexes
Kou, Yingying
Tian, Jinlei
Li, Dongdong
Gu, Wen
Liu, Xin
Yan, Shiping
Liao, Daizheng
Cheng, Peng
DALTON TRANSACTIONS, 2009, (13) : 2374 - 2382
[22] Heteroleptic ruthenium(II)/(III) 2,2′-bipyridine/1,10-phenanthroline complexes incorporating bidentate Schiff base N,O-ligands
Wang, Chang-Jiu
Xu, Wen-Fang
Tong, Bi-Hai
Jia, Ai-Quan
Zhang, Qian-Feng
JOURNAL OF COORDINATION CHEMISTRY, 2017, 70 (10) : 1617 - 1631
[23] Plasmid DNA Cleavage by Valine-Schiff Base-Cu Complexes
Wang Chang-Rong
Lue Jian
Gao Lu
Wang Yong-Mei
Zhang Jin-Hong
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2008, 29 (11): : 2201 - 2204
[24] DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand
Rodriguez, Maria R.
Lavecchia, Martin J.
Parajon-Costa, Beatriz S.
Gonzalez-Baro, Ana C.
Gonzalez-Baro, Maria R.
Cattaneo, Elizabeth R.
BIOCHIMIE, 2021, 186 : 43 - 50
[25] Synthesis, Characterization, and DNA Binding and Cleavage Properties of Copper(II)-tryptophanphenylalanine-1,10-phenanthroline/2,2′-bipyridine Complexes
Reddy, Pulimamidi R.
Raju, Nomula
Satyanarayana, Battu
CHEMISTRY & BIODIVERSITY, 2011, 8 (01) : 131 - 144
[26] HECTORITE COMPLEXES WITH CU(II) AND FE(II)-1,10-PHENANTHROLINE CHELATES
BERKHEISER, VE
MORTLAND, MM
CLAYS AND CLAY MINERALS, 1977, 25 (02) : 105 - 112
[27] Oxidative Carbonylation of Methanol to Dimethyl Carbonate Over Cu(II)-1,10-Phenanthroline Bromide Complexes
Du, Zhiping
Xiong, Lihua
Lin, Zhikun
Li, Xuli
Ding, Yigang
Wu, Yuanxin
CHINESE JOURNAL OF CHEMICAL ENGINEERING, 2014, 22 (10) : 1117 - 1121
[28] Sensitized luminescence of Eu(III) complexes with Schiff-base and 1,10-phenanthroline: Role of Schiff-base as a sensitizer
Lee, Jong Cheol
Jeong, Yong-Kwang
Kim, Jong-Moon
Kang, Jun-Gill
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 124 : 256 - 264
[29] Aerobic oxidation of 1,10-phenanthroline to phen-dione catalyzed by copper(II) complexes of a benzimidazolyl Schiff base
Kumar, Ravinder
Mathur, Pavan
RSC ADVANCES, 2014, 4 (63) : 33190 - 33193
[30] Synthesis, Characterization, Photoluminescence Properties and Antiproliferative Activity of New Pd(II), Ni(II) and Cu(II) Mixed Complexes Bearing Schiff Base Ligand and 1,10-phenanthroline
Sogukomerogullari, Hatice Gamze
Basaran, Eyup
Sarioglu, Ahmet Oral
Kose, Aysegul
Akkoc, Senem
CHEMISTRYSELECT, 2023, 8 (24):

← 1 2 3 4 5 →