Association of polymorphic markers of the lipid metabolism genes with diabetic polyneuropathy in type 1 diabetes mellitus

被引：1

作者：

Voron'ko, OE ^{[1
]}

Yakunina, NY

Strokov, IA

Lavrova, IN

Nosikov, VV

机构：

[1] State Res Ctr GosNIIGenet, Moscow 117545, Russia

[2] Sechenov Moscow Med Acad, Moscow 119021, Russia

[3] Russian Med Acad Postgrad Educ, Moscow 125315, Russia

来源：

MOLECULAR BIOLOGY | 2005年 / 39卷 / 02期

关键词：

type 1 diabetes mellitus; diabetic polyneuropathy; polymorphic markers; APOE; APOB; polymerase chain reaction; human;

D O I：

10.1007/s11008-005-0030-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A possible association of the polymorphic markers epsilon 2/epsilon 3/epsilon 4 of the apolipoprotein E gene (APOE) and I/D of the apolipoprotein B gene (APOB) with diabetic polyneuropathy (DPN) was analyzed in patients with type I diabetes mellitus (T1DM) with (N = 86) or without (N = 94) clinical signs of DPN, The two groups did not differ significantly in allele and genotype frequencies of the epsilon 2/epsilon 3/epsilon 4 polymorphic marker ofthe APOE gene. Analysis of the allele and genotype frequency distributions of the I/D polymorphic marker of the APOB gene showed that risk of DPN is higher in carriers of allele I or genotype I/I (OR = 1.66 and 2.01, respectively) and lower in carriers of allele D (OR = 0.60). The results implicate the APOB gene. which codes for one of the major components of the lipid metabolism system, in DPN development in patients with T1DM.

引用

页码：206 / 209

页数：4

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