Yang-Gan-Wan protects mice against apoptosis induced by anti-fas antibody (Jo2)

被引：4
|
作者：
Yang, M [1 ]
Chen, K [1 ]
Shih, JC [1 ]
机构：
[1] Univ So Calif, Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90089 USA
来源：
AMERICAN JOURNAL OF CHINESE MEDICINE | 2000年 / 28卷 / 3-4期
关键词：
D O I：
10.1142/S0192415X00000386
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
We investigated the protective effect of Yang-Gan-Wan (YGW, Pro-Liver pill), a Chinese herbal remedy, against liver apoptosis (programmed cell death) induced by anti-Fas antibody (Jo2). Mice were pretreated daily with 200 mg/kg YGW for 14 days before treatment with 10 mug/20 kg body weight Jo2. YGW significantly reduced the elevated activity of alanine aminotransferase (ALT) and also reduced the elevated activity of sorbitol dehydrogenase (SDH) produced 4 hrs after treatment with Jo2. YGW also increased the survival of mice treated with Jo2 by about 1 hr in 11 out of 16 mice (69 %). Most of the mice died 9 hrs after Jo2 injection. This study demonstrates that YGW has protective effects against liver apoptosis induced by Jo2.
引用
收藏
页码：325 / 330
页数：6
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