Asymmetric Direct Vinylogous Aldol Reaction of Unactivated γ-Butenolide to Aldehydes

被引：55
|
作者：
Yang, Yang [1 ]
Zheng, Ke [1 ]
Zhao, Jiannan [1 ]
Shi, Jian [1 ]
Lin, Lili [1 ]
Liu, Xiaohua [1 ]
Feng, Xiaoming [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 15期
基金：
中国国家自然科学基金;
关键词：
NAFUREDIN-GAMMA; BRONSTED ACID; MANNICH-TYPE; 2-(TRIMETHYLSILYLOXY)FURAN; 2-TRIMETHYLSILYLOXYFURAN; ORGANOCATALYSIS; LAMBERTELLOLS; DERIVATIVES; ACTIVATION; CATALYSIS;
D O I：
10.1021/jo100946d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide with aldehydes has been developed, giving the corresponding 5-(1'-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83% ee) under mild conditions.
引用
收藏
页码：5382 / 5384
页数：3
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