Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis

被引：24

作者：

Lingscheid, Tilman ^{[1
,2
,3
]}

Kinzig, Martina ^{[4
]}

Krueger, Anne ^{[2
,3
,5
]}

Mueller, Nils ^{[2
,3
,5
]}

Boelke, Georg ^{[2
,3
,5
]}

Tober-Lau, Pinkus ^{[1
,2
,3
]}

Muenn, Friederike ^{[1
,2
,3
]}

Kriedemann, Helene ^{[1
,2
,3
]}

Witzenrath, Martin ^{[1
,2
,3
,6
]}

Sander, Leif E. ^{[1
,2
,3
,6
,7
]}

Soergel, Fritz ^{[4
,8
]}

Kurth, Florian ^{[1
,2
,3
,9
]}

机构：

[1] Charite Univ Med Berlin, Dept Infect Dis & Resp Med, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] IBMP Inst Biomed & Pharmaceut Res, Nurnberg, Germany

[5] Charite Univ Med Berlin, Dept Nephrol & Intens Care, Berlin, Germany

[6] DZL, German Ctr Lung Res, Berlin, Germany

[7] Berlin Inst Hlth, Berlin, Germany

[8] Univ Duisburg Essen, West German Heart & Vasc Ctr, Inst Pharmacol, Essen, Germany

[9] Bernhard Nocht Inst Trop Med, Dept Trop Med, Hamburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 11期

关键词：

COVID-19; end-stage renal disease; hemodialysis; nirmatrelvir/ritonavir; Paxlovid; PLASMA;

D O I：

10.1128/aac.01229-22

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nirmatrelvir/ritonavir is an effective antiviral therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Use is not recommended in patients with end-stage renal disease (ESDR) due to a lack of data. We investigated the pharmacokinetics of nirmatrelvir/ritonavir (150 mg/100 mg twice a day) in four patients with ESRD undergoing hemodialysis. Nirmatrelvir peak concentrations ranged from 4,563 to 7,898 ng/ mL and declined after hemodialysis. Concentrations were up to 4-fold higher but still within the range known from patients without ESRD, without accumulation of nirmatrelvir after the end of treatment.

引用

页数：4

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