Serological correlations with nephritis in systemic lupus erythematosus

被引：14

作者：

Reichlin, M

机构：

[1] Oklahoma Med Res Fdn, Arthrit Immunol Program, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Rheumatol Immunol & Allergy Sect, Oklahoma City, OK 73104 USA

来源：

CLINICAL IMMUNOLOGY | 2005年 / 117卷 / 01期

关键词：

anti-lipoprotein lipase; autoantibody synergy; lupus nephritis; anti-ribosomal P; pathogenesis;

D O I：

10.1016/j.clim.2005.06.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies have long been thought to participate in the pathogenesis of lupus nephritis. In this regard, antibodies to double stranded (ds)DNA and ribosomal P protein have been studied the most intensively. We now report a new specificity, antibodies to lipoprotein lipase (LPL) that is strongly associated with lupus nephritis and has a powerful synergistic effect with anti-ribosomal P antibodies in its association with nephritis. The recognition of anti-LPL antibodies and their synergy with anti-P antibodies are discussed in terms of the pathogenesis of lupus nephritis. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：12 / 14

页数：3

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