Current Progress and Prospects in Rabbit Cloning

被引：1
|
作者：
Cao, Wenbin [1 ]
Zhao, Jinpeng [1 ]
Qu, Pengxiang [1 ]
Liu, Enqi [1 ]
机构：
[1] Xi An Jiao Tong Univ, Hlth Sci Ctr, Lab Anim Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China
来源：
CELLULAR REPROGRAMMING | 2022年 / 24卷 / 02期
基金：
中国博士后科学基金;
关键词：
somatic cell nuclear transfer; reprogramming; rabbit; CELL NUCLEAR TRANSFER; FULL-TERM DEVELOPMENT; CLONED RABBITS; DNA METHYLTRANSFERASES; EXOGENOUS EXPRESSION; DONOR CELLS; PROTAMINE; SCNT; EMBRYOS; MODEL;
D O I：
10.1089/cell.2021.0090
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Somatic cell nuclear transfer (SCNT) shows great value in the generation of transgenic animals, protection of endangered animals, and stem cell therapy. The combination of SCNT and gene editing has produced a variety of genetically modified animals for life science and medical research. Rabbits have unique advantages as transgenic bioreactors and human disease models; however, the low SCNT efficiency severely impedes the application of this technology. The difficulty in SCNT may be attributable to the abnormal reprogramming of somatic cells in rabbits. This review focuses on the abnormal reprogramming of cloned mammalian embryos and evaluates the progress and prospects of rabbit somatic cell cloning.
引用
收藏
页码：63 / 70
页数：8
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