Design and synthesis of potent DNA alkylating indolino-benzodiazepine compounds (BIAs) linked with a DNA binding moiety for use in antibody-drug conjugates (ADCs)

被引：0

作者：

Reid, Emily ^{[1
]}

Archer, Katie ^{[1
]}

Shizuka, Manami ^{[1
]}

McShea, Molly ^{[1
]}

Maloney, Erin ^{[1
]}

Ab, Olga ^{[1
]}

Lanieri, Leanne ^{[1
]}

Wilhelm, Alan ^{[1
]}

Ponte, Jose ^{[1
]}

Yoder, Nicholas ^{[1
]}

Chari, Ravi ^{[1
]}

Miller, Michael ^{[1
]}

机构：

[1] Immunogen Inc, Waltham, MA USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 256卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

363

引用

页数：1

共 25 条

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[23] Design, synthesis and evaluation of a novel DNA-interactive agent: A promising new class of cytotoxic molecules for use in antibody-drug conjugates
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[24] Potent antigen-specific anti-tumor activity observed with antibody-drug conjugates (ADCs) made using a new class of DNA-crosslinking agents
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[25] Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (08) : 2594 - 2598

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