Lsh controls Hox gene silencing during development

被引：65
|
作者：
Xi, Sichuan [1 ]
Zhu, Heming [1 ]
Xu, Hong [1 ]
Schmidtmann, Anja [1 ]
Geiman, Theresa M. [1 ]
Muegge, Kathrin [1 ]
机构：
[1] NCI, Lab Canc Prevent, SAIC Frederick, Frederick, MD 21702 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 36期
关键词：
chromatin; DNA methylation; polycomb; Lsh;
D O I：
10.1073/pnas.0703669104
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Polycomb-mediated repression and DNA methylation are important epigenetic mechanisms of gene silencing. Recent evidence suggests a functional link between the polycomb repressive complex (PRC) and Dnmts in cancer cells. Here we provide evidence that Lsh, a regulator of DNA methylation, is also involved in normal control of PRC-mediated silencing during embryogenesis. We demonstrate that Lsh, a SNF2 homolog, can associate with some Hox genes and regulates Dnmt3b binding, DNA methylation, and silencing of Hox genes during development. Moreover, Lsh can associate with PRO components and influence PRC-mediated histone modifications. Thus Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of PRC targets.
引用
收藏
页码：14366 / 14371
页数：6
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