Were the wrong cells studied?

被引:1
|
作者
Koppe, Janna [1 ]
Ten Tusscherb, Gavin W. [2 ]
机构
[1] Univ Amsterdam, Emma Childrens Hosp AMC, Dept Pulmonol, NL-3634 AT Loenersloot, Netherlands
[2] Westfriesgasthuis, Dept Paediat & Neonatol, Hoorn, Netherlands
关键词
Lymphocytes; Polymorphonuclear leucocytes; Ah-receptor; Dioxin; Dioxin-like compound; Toxic equivalent factor (TEF); EXPOSURE; EXPRESSION; DIOXINS;
D O I
10.1016/j.toxlet.2014.10.002
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Peripheral blood lymphocytes (PBL) studying the effects of dioxins and dioxin-like compounds in vitro is not correct. Peripheral lymphocytes in general (Th1, Th2) do not have an Ah-receptor. Polymorphonuclear leucocytes (PMN's) are more logical to use. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:542 / 543
页数:2
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