Subharmonic Synchronization of Picosecond Yb Fiber Laser to Picosecond Ti:Sapphire Laser for Stimulated Raman Scattering Microscopy

被引：8

作者：

Umemura, Wataru ^{[1
]}

Fujita, Kenta ^{[1
]}

Ozeki, Yasuyuki ^{[1
,2
]}

Goto, Ken ^{[3
]}

Sumimura, Kazuhiko ^{[1
]}

Nishizawa, Norihiko ^{[4
]}

Fukui, Kiichi ^{[3
]}

Itoh, Kazuyoshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Mat & Life Sci, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Agcy JST, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan

[4] Nagoya Univ, Grad Sch Engn, Dept Elect Engn & Comp Sci, Nagoya, Aichi 4648603, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS | 2012年 / 51卷 / 02期

关键词：

EMISSION MICROSCOPY; SENSITIVITY; FLUORESCENCE; GENERATION;

D O I：

10.1143/JJAP.51.022702

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We demonstrate a subharmonically synchronized picosecond laser system and its application to stimulated Raman scattering (SRS) microscopy for label-free biological imaging with high sensitivity and high spectral resolution. Experimentally, 5.5-ps Yb fiber laser pulses at a repetition rate of 38 MHz were successfully synchronized to 4.8-ps Ti:Sapphire laser pulses at a repetition rate of 76 MHz, by using a two-photon detector, an intracavity electro-optic modulator, and a piezoelectric transducer. The temporal jitter was measured to be 120 fs. These pulses were applied to SRS microscopy. We confirmed the shot-noise-limited sensitivity, and succeeded in SRS spectroscopy of a polymer bead as well as three-dimensional SRS imaging of a HeLa cell. (C) 2012 The Japan Society of Applied Physics

引用

页数：4

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