Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women

被引:37
|
作者
Hao, Shuang [1 ,2 ]
Liu, Yin [1 ,2 ]
Yu, Ke-Da [1 ,2 ]
Chen, Sheng [1 ,2 ]
Yang, Wen-Tao [2 ,3 ]
Shao, Zhi-Min [1 ,2 ,4 ,5 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Dept Breast Surg, Shanghai 200433, Peoples R China
[2] Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai 200433, Peoples R China
[3] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai 200433, Peoples R China
[4] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
[5] Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Dept Breast Surg, Shanghai 200433, Peoples R China
来源
PLOS ONE | 2015年 / 10卷 / 06期
关键词
BODY-MASS INDEX; ESTROGEN-RECEPTOR; POOLED ANALYSIS; DISEASE-FREE; SURVIVAL; OBESITY; IMPACT; SUBTYPES; WEIGHT;
D O I
10.1371/journal.pone.0129741
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose Obesity is associated with poorer outcomes in patients with hormone receptor-positive breast cancers, but this association is not well established for women with triple-negative breast cancers (TNBC). Here, we investigated the prognostic effects of body mass index (BMI) on clinical outcomes in patients with TNBC. Methods We identified 1106 patients with TNBC who met the inclusion criteria and were treated between January 2002 and June 2012. Clinical and biological features were collected to evaluate the relation between BMI and breast cancer-specific survival (BCSS) and overall survival (OS) after controlling for other clinically significant variables. Results Of 1106 patients, 656 (59.3%) were normal weight (BMI <= 24) and 450 patients (40.7%) were overweight(BMI>24). Median follow-up time was 44.8 months. Breast cancer specific death was observed in 140 patients. After adjusting for clinicopathologic risk factors, overweight was associated with OS (hazard ratio [HR]: 1.46, 95% confidence interval [CI]: 1.04-2.06, P = 0.028) but not BCSS (HR: 1.34, 95% CI: 0.90-2.01, P = 0.15) in all the patients with TNBC. When stratified with menopausal status, overweight was associated with BCSS and OS (HR: 2.27, 95% CI: 1.11-4.63, P = 0.024 and HR: 2.16, 95% CI: 1.21-3.87, P = 0.010, respectively) in premenopausal women. BMI was not associated with BCSS or OS in postmenopausal women. Conclusions Overweight is an independent prognostic factor of OS in all women with TNBC, and menopause status may be a mitigating factor. Among premenopausal women, overweight women are at a greater risk of poor prognosis than normal weight women. If validated, these findings should be considered in developing preventive programs.
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页数:10
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