Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy

被引:13
|
作者
Leon Rodriguez, Daniel A. [1 ]
David Carmona, F. [1 ]
Isabel Gonzalez, Clara [2 ]
Martin, Javier [1 ]
机构
[1] CSIC, IPBLN, PTS, Granada, Spain
[2] Univ Ind Santander, Fac Salud, GIEM, Bucaramanga, Colombia
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词
VITAMIN-D-RECEPTOR; DISEASE; SUSCEPTIBILITY; ASSOCIATION; SEVERITY; DENSITY; MALARIA; ALPHA; IL12B; MICE;
D O I
10.1038/srep31263
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed. Due to the high relevance of this signaling pathway, several studies have investigated the possible influence of genes involved in the metabolism of Vitamin D and its receptor in different human diseases. Here, we analyzed whether four single-nucleotide polymorphisms of the VDR gene (rs731236, rs7975232, rs1544410 and rs2228570) are involved in the susceptibility to infection by Trypanosoma cruzi and/or to chronic Chagas cardiomyopathy (CCC) in a Colombian endemic population for this parasite. Our results showed that the rs2228570*A allele is associated with CCC development (P = 4.46E-03, OR = 1.51). In summary, the data presented in this report suggest that variation within the VDR gene may affect the immune response against T. cruzi, increasing the probability of cardiac complications in infected individuals.
引用
收藏
页数:6
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