Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin

被引：14
|
作者：
Pérez-Guerrero, C [1 ]
Márquez-Martín, A [1 ]
Herrera, MD [1 ]
Marhuenda, E [1 ]
de Sotomayor, MA [1 ]
机构：
[1] Univ Seville, Fac Pharm, Dept Pharmacol, ES-41012 Seville, Spain
来源：
PHARMACOLOGY | 2005年 / 74卷 / 04期
关键词：
HMG-CoA reductase; simvastatin; calcium; Rho-kinase; spontaneously hypertensive rat;
D O I：
10.1159/000085957
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The acute effect of simvastatin on aortic rings from spontaneously hypertensive rats (SHRs) was identified. Simvastatin-evoked relaxations of both depolarized and phenylephrine-precontracted arteries were independent of the presence of endothelium. This effect was inhibited by diltiazem and mevalonate, but not by the Rho-kinase inhibitor, Y-27632. Simvastatin prevented contraction induced by phenylephrine, calcium ionophore A-23187 and CaCl2 in Ca2+- free medium. Y-27632 decreased the effect of simvastatin. On the contrary, contraction induced by noradrenaline in Ca2+- free medium was not affected. These results suggest that simvastatin elicited an effect on vascular smooth muscle cells from SHRs that may involve blockade of extracellular calcium entry and decrease vascular contraction by affecting Rho-kinase. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码：209 / 215
页数：7
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