Influence of stromal-epithelial interactions on androgen action

被引：27
|
作者：
Nieto, Cera M. [1 ]
Rider, Leah C. [1 ]
Cramer, Scott D. [1 ]
机构：
[1] Univ Colorado, Dept Pharmacol, Aurora, CO 80045 USA
来源：
ENDOCRINE-RELATED CANCER | 2014年 / 21卷 / 04期
关键词：
androgens; androgen receptor; breast; prostate; BENIGN PROSTATIC HYPERPLASIA; KERATINOCYTE GROWTH-FACTOR; NEGATIVE BREAST-CANCER; FEMINIZED TFM/Y MICE; CARCINOMA-ASSOCIATED FIBROBLASTS; UROGENITAL SINUS MESENCHYME; RAT VENTRAL PROSTATE; MOUSE MAMMARY-GLAND; RECEPTOR EXPRESSION; MALIGNANT-TRANSFORMATION;
D O I：
10.1530/ERC-14-0138
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Androgen receptor (AR) signaling is vital to the development and function of the prostate and is a key pathway in prostate cancer. AR is differentially expressed in the stroma and epithelium, with both paracrine and autocrine control throughout the prostate. Stromalepithelial interactions within the prostate are commonly dependent on AR signaling and expression. Alterations in these pathways can promote tumorigenesis. AR is also expressed in normal and malignant mammary tissues. Emerging data indicate a role for AR in certain subtypes of breast cancer that has the potential to be exploited therapeutically. The aim of this review is to highlight the importance of these interactions in normal development and tumorigenesis, with a focus on the prostate and breast.
引用
收藏
页码：T147 / T160
页数：14
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