High daily fraction dose external radiotherapy for T1 glottic carcinoma: Treatment results and prognostic factors

被引：16
|
作者：
Gultekin, Melis [1 ]
Ozyar, Enis [1 ]
Cengiz, Mustafa [1 ]
Ozyigit, Gokhan [1 ]
Hayran, Mutlu [2 ]
Hosal, Sefik [3 ]
Akyol, Fadil [1 ]
机构：
[1] Hacettepe Univ, Fac Med, Dept Radiat Oncol, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Prevent Oncol, TR-06100 Ankara, Turkey
[3] Hacettepe Univ, Fac Med, Dept Ear Nose & Throat Surg, TR-06100 Ankara, Turkey
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 07期
关键词：
larynx; early glottic carcinoma; radiotherapy; prognostic factors; SQUAMOUS-CELL CARCINOMA; LOCAL-CONTROL; RADIATION-THERAPY; TREATMENT TIME; LARYNX; CANCER; SIZE; COMPLICATIONS; IMPACT;
D O I：
10.1002/hed.21860
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background The purpose of this study was to investigate the prognostic factors and treatment results of T1N0M0 glottic laryngeal carcinoma irradiated with 2.3 Gray (Gy) per fraction. Methods A total of 183 patients with glottic carcinoma treated between June 1998 and January 2007 were retrospectively evaluated. Of the 183 patients, 163 patients (89%) had T1a and 20 patients (11%) had T1b disease. All patients received 2.3 Gy per fraction to a median total dose of 64.4 Gy. Results The median follow-up was 63 months. The 5-year overall survival (OS), local control, and cancer-specific survival rates were 89%, 81%, and 90%, respectively. Multivariate analysis showed overall treatment time and age to be significant prognostic factors for local control and OS. We observed no grade IV or grade V acute toxicity. Tracheaesophageal fistula as late toxicity was observed in only 1 patient. Conclusions High daily fraction scheme seems to be a feasible schedule for early glottic carcinomas. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012
引用
收藏
页码：1009 / 1014
页数：6
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