Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

被引：23

作者：

Gandy, S ^{[1
]}

DeMattos, RB

Lemere, CA

Heppner, FL

Leverone, J

Aguzzi, A

Ershler, WB

Dai, JL

Fraser, P

Hyslop, PSG

Holtzman, DM

Walker, LC

Keller, ET

机构：

[1] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA

[2] Washington Univ, St Louis, MO USA

[3] Harvard Univ, Inst Med, Womens Hosp Ctr Neurol Dis, Boston, MA 02115 USA

[4] Brigham Med Inst, Womens Hosp Ctr Neurol Dis, Boston, MA USA

[5] Univ Zurich, Zurich, Switzerland

[6] Inst Adv Studies Aging & Geriatr Med, Washington, DC USA

[7] Univ Michigan, Dept Lab Anim Med, Ann Arbor, MI 48109 USA

[8] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[9] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 02期

关键词：

Alzheimers; Alzheimer's vaccination; rhesus monkey; immunization;

D O I：

10.1016/j.mad.2003.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). immunized monkeys developed anti-Abeta titers exceeding 1: 1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：149 / 151

页数：3

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