The Long-Term Safety and Quality of Life Effects of Oats in Dermatitis Herpetiformis

被引:8
|
作者
Alakoski, Anna [1 ,2 ]
Hervonen, Kaisa [1 ,2 ]
Mansikka, Eriika [2 ]
Reunala, Timo [1 ,2 ]
Kaukinen, Katri [2 ,3 ]
Kivela, Laura [2 ]
Laurikka, Pilvi [2 ]
Huhtala, Heini [4 ]
Kurppa, Kalle [5 ,6 ,7 ,8 ]
Salmi, Teea [1 ,2 ]
机构
[1] Tampere Univ Hosp, Dept Dermatol, Tampere 33521, Finland
[2] Tampere Univ, Fac Med & Hlth Technol, Celiac Dis Res Ctr, Tampere 33014, Finland
[3] Tampere Univ Hosp, Dept Internal Med, Tampere 33521, Finland
[4] Tampere Univ, Fac Social Sci, Tampere 33014, Finland
[5] Tampere Univ Hosp, Dept Paediat, Tampere 33521, Finland
[6] Tampere Univ, Ctr Child Hlth Res, Tampere 33521, Finland
[7] Seinajoki Cent Hosp, Dept Pediat, Seinajoki 60220, Finland
[8] Univ Consortium Seinajoki, Seinajoki 60220, Finland
基金
芬兰科学院;
关键词
dermatitis herpetiformis; coeliac disease; gluten-free diet; oats; quality of life; complications; follow-up; GLUTEN-FREE DIET; CELIAC-DISEASE; FOLLOW-UP; TRANSGLUTAMINASE ANTIBODIES; GASTROINTESTINAL SYMPTOMS; TISSUE TRANSGLUTAMINASE; VILLOUS ATROPHY; SKIN-LESIONS; PREVALENCE; ADULTS;
D O I
10.3390/nu12041060
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The treatment of choice for dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is a life-long gluten-free diet (GFD). In a GFD, wheat, rye and barley should be strictly avoided, but the role of oats is more controversial. This study aimed to investigate the safety and long-term quality of life and health effects of oat consumption in 312 long-term treated DH patients. Baseline data were gathered from patient records and follow-up data from questionnaires or interviews, and validated questionnaires were used to assess quality of life. We found that altogether 256 patients (82%) were consuming oats as part of their GFD at the follow-up. Long-term follow-up data showed that there were no differences in the presence of long-term illnesses, coeliac disease complications or the usage of medication between those consuming and not consuming oats. However, oat consumers had a better quality of life and reported ongoing gastrointestinal symptoms less frequently (4% vs 19%, p = 0.004) at the follow-up than those not consuming oats. The study established that oats are safe for DH patients and in the long-term seem to improve the quality of life of DH patients.
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页数:10
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