Properties of biomineralized (CaCO3) PVP-CMC hydrogel with reference to its cytotoxicity

被引：11
|
作者：
Shah, Rushita [1 ]
Saha, Nabanita [1 ]
Kucekova, Zdenka [1 ]
Humpolicek, Petr [1 ]
Saha, Petr [1 ]
机构：
[1] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Czech Republic
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2016年 / 65卷 / 12期
关键词：
Biomineralization; CaCO3; cytotoxicity; modulus; PVP-CMC; CARBOXYMETHYL CELLULOSE; TISSUE; MINERALIZATION; BIOCOMPATIBILITY; HYDROXYAPATITE; CRYSTALS;
D O I：
10.1080/00914037.2016.1157793
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The authors focus on properties of biomineralized (CaCO3) PVP-CMC hydrogel (designated as I-X) including cytotoxicity assay using primary mouse embryonic fibroblasts. The biomineralized samples (VII-X) showed >80% cell viability, was selected for further characterizations. FTIR and XRD indicate deposition of CaCO3 within the PVP-CMC hydrogel matrix, SEM shows changes in morphology and pore diameter (VII and VIII: 1-12 mu m; IX: 10-70 mu m; X: 70-170 mu m), TGA determines the decomposition scenario of CaCO3, and tensile strength of samples (VII-X) ranged between 0.04 and 1.0GPa, which practically corresponds to the modulus of cancellous bone.
引用
收藏
页码：619 / 628
页数：10
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