Gas-Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO-Catalyzed Aerobic Oxidation of Primary Alcohols

被引：31

作者：

Vanoye, Laurent ^{[1
]}

Pablos, Mertxe ^{[1
]}

de Bellefon, Claude ^{[1
]}

Favre-Reguillon, Alain ^{[1
,2
]}

机构：

[1] CPE Lyon, Lab Genie Proc Catalyt, F-69100 Villeurbanne, France

[2] CASER SITI, Conservatoire Natl Arts & Metiers, F-75003 Paris, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 04期

关键词：

aerobic oxidation; alcohols; copper; flow chemistry; 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO); COPPER(I)/TEMPO CATALYST; ROOM-TEMPERATURE; AQUEOUS AMMONIA; PROCESS WINDOWS; ALDEHYDES; REACTORS; MECHANISM; AMINES; OXYGEN; NITRILES;

D O I：

10.1002/adsc.201400925

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Aerobic oxidation using a combination of copper salts and 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas-liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover-limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.

引用

页码：739 / 746

页数：8

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