Prognostic Predictive Characteristics in Patients With Fibrosing Interstitial Lung Disease: A Retrospective Cohort Study

被引:10
|
作者
Wang, Yuanying [1 ]
Guo, Ziyun [1 ]
Ma, Ruimin [1 ]
Wang, Jingwei [1 ]
Wu, Na [1 ,2 ]
Fan, Yali [1 ]
Ye, Qiao [1 ,2 ]
机构
[1] Capital Med Univ, Beijing Chaoyang Hosp, Beijing Inst Resp Med, Clin Ctr Interstitial Lung Dis, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Chaoyang Hosp, Dept Occupat Med & Toxicol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
progressive fibrosing interstitial lung disease; prognosis; lung function test; blood count values; anti-fibrotic treatment; IDIOPATHIC PULMONARY-FIBROSIS; PIRFENIDONE; DIAGNOSIS;
D O I
10.3389/fphar.2022.924754
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Limited data are available regarding the entire spectrum of interstitial lung disease with a progressive fibrosing feature. We investigated the prevalence and prognostic predictive characteristics in patients with PF-ILD.Methods: This retrospective cohort study included patients with fibrosing ILD who were investigated between 1 January 2015 and 30 April 2021. We recorded clinical features and outcomes to identify the possible risk factors for fibrosing progression as well as mortality.Results: Of the 579 patients with fibrosing ILD, 227 (39.21%) met the criteria for progression. Clubbing of fingers [odds ratio (OR) 1.52, 95% confidence interval (CI) 1.03 to 2.24, p = 0.035] and a high-resolution computed tomography (HRCT)-documented usual interstitial pneumonia (UIP)-like fibrotic pattern (OR 1.95, 95% CI 1.33 to 2.86, p = 0.001) were risk factors for fibrosis progression. The mortality was worse in patients with PF with hypoxemia [hazard ratio (HR) 2.08, 95% CI 1.31 to 3.32, p = 0.002], in those with baseline diffusion capacity of the lung for carbon monoxide (DLCO) % predicted <50% (HR 2.25, 95% CI 1.45 to 3.50, p < 0.001), or in those with UIP-like fibrotic pattern (HR 1.68, 95% CI 1.04 to 2.71, p < 0.001).Conclusion: Clubbing of fingers and an HRCT-documented UIP-like fibrotic pattern were more likely to be associated with progressive fibrosing with varied prevalence based on the specific diagnosis. Among patients with progressive fibrosing, those with hypoxemia, lower baseline DLCO% predicted, or UIP-like fibrotic pattern showed poor mortality.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] Pirfenidone in Patients with Unclassifiable Progressive Fibrosing Interstitial Lung Disease: Demographic and Baseline Characteristics
    Maher, T. M.
    Corte, T. J.
    Fischer, A.
    Kreuter, M.
    Lederer, D. J.
    Molina-Molina, M.
    Samara, K.
    Axmann, J.
    Kirchgaessler, K.
    Cottin, V.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [22] INTERSTITIAL LUNG DISEASE: RETROSPECTIVE STUDY OF THE PROGNOSTIC IMPACT OF ACUTE EXACERBATIONS
    Pacheco, Joana M.
    Santos, Ana I.
    Catarata, Joana
    Freitas, Sara
    SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 2024, 41 (04)
  • [23] Prognostic Analysis of Pneumocystis Jirovecii Pneumonia in Interstitial Lung Disease Patients: A Retrospective Clinical Study
    Sun, Yuxin
    Shao, Chi
    Huang, Hui
    Chen, Ruxuan
    Xu, Kai
    Li, Mei
    Zhang, Xin
    Xu, Zuojun
    DIAGNOSTICS, 2022, 12 (12)
  • [24] A retrospective study on the predictive implications of clinical characteristics and therapeutic management in patients with rheumatoid arthritis-associated interstitial lung disease
    Li, Luling
    Liu, Ran
    Zhang, Yongfeng
    Zhou, Junfei
    Li, Yifan
    Xu, Yuetong
    Gao, Shuai
    Zheng, Yi
    CLINICAL RHEUMATOLOGY, 2020, 39 (05) : 1457 - 1470
  • [25] A retrospective study on the predictive implications of clinical characteristics and therapeutic management in patients with rheumatoid arthritis-associated interstitial lung disease
    Luling Li
    Ran Liu
    Yongfeng Zhang
    Junfei Zhou
    Yifan Li
    Yuetong Xu
    Shuai Gao
    Yi Zheng
    Clinical Rheumatology, 2020, 39 : 1457 - 1470
  • [26] Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort
    Ying, Yanan
    Wu, Tingting
    Wang, Long
    Zhang, Yun
    Yu, Yiming
    Deng, Zaichun
    Ding, Qunli
    ORPHANET JOURNAL OF RARE DISEASES, 2025, 20 (01)
  • [27] Interstitial lung disease associated with gemcitabine: A Japanese retrospective cohort study
    Hamada, Tsuyoshi
    Yasunaga, Hideo
    Nakai, Yousuke
    Isayama, Hiroyuki
    Matsui, Hiroki
    Fushimi, Kiyohide
    Koike, Kazuhiko
    RESPIROLOGY, 2016, 21 (02) : 338 - 343
  • [28] Progression of fibrosing interstitial lung disease
    Alyson W. Wong
    Christopher J. Ryerson
    Sabina A. Guler
    Respiratory Research, 21
  • [29] Baseline characteristics and survival of Progressive Fibrosing Interstitial Lung Disease in Rheumatoid Arthritis. A single center retrospective study.
    Caro, F. M.
    Donati, P.
    Ruiz, R.
    Auteri, S.
    Fassola, L.
    Fernandez, M. E.
    Barbich, T.
    Alberti, M. L.
    EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [30] Predictive Findings of Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
    Lima Resende, Ana Carolina
    Mancuzo, Eliane Viana
    Soares, Maria Raquel
    Cavalcante Neto, Paulo Miranda
    Moreira, Maria Auxiliadora
    Neves Arantes, Leticia Ferreira
    Carlos Tibana, Regina Celia
    De Aguiar Baptista, Fernanda Maciel
    Galvao Nonato Alves, Tatiana Senna
    Storrer, Karin Mueller
    De Oliveira, Priscila Isolani
    Machado Nogueira, Fernanda Maria Pinheiro
    Martins, Rafaela Boaventura
    Krupok Matias, Simone Lobo
    Cordero Da Silva, Soraya Abou El Hosn
    Arida, Vanessa El Mir
    Botelho, Andre Bezerra
    De Moraes Beraldo, Bruno Leoncio
    Cunha Castro, Marina Dornfeld
    Fukuda, Cesar Yoshito
    Cerezoli, Milena Tenorio
    Ferreira, Rimarcs Gomes
    Missrie, Israel
    Pereira, Carlos
    EUROPEAN RESPIRATORY JOURNAL, 2021, 58