Rotaxanes and Biofunctionalized Pseudorotaxanes via Thiol-Maleimide Click Chemistry

被引：17
|
作者：
Choudhary, Umesh [1 ]
Northrop, Brian H. [1 ]
机构：
[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 08期
关键词：
CROWN-ETHERS; DONOR; MACHINES; INTERLOCKING; DERIVATIVES; COMPONENTS; SHUTTLES; COMPLEX;
D O I：
10.1021/ol300614z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Base-catalyzed thiol-maleimide click chemistry has been applied to the synthesis of neutral donor-acceptor [2]rotaxanes in good yield. This method is extended further to the synthesis of a glutathione-functionalized [2]pseudorotaxane, a precursor to integrated conjugates of interlocked molecules with proteins and enzymes.
引用
收藏
页码：2082 / 2085
页数：4
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