Clinical and Virologic Response to Episodic Acyclovir for Genital Ulcers Among HIV-1 Seronegative, Herpes Simplex Virus Type 2 Seropositive African Women: A Randomized, Placebo-Controlled Trial

被引：6

作者：

Baeten, Jared M. ^{[1
,2
,3
]}

Reid, Stewart E. ^{[4
,5
]}

Delany-Moretlwe, Sinead ^{[6
]}

Hughes, James P. ^{[7
]}

Wang, Richard S. ^{[1
]}

Wilcox, Ellen ^{[1
]}

Limbada, Mohammed ^{[5
]}

Akpomiemie, Godspower ^{[6
]}

Corey, Lawrence ^{[2
,8
,9
]}

Wald, Anna ^{[2
,3
,8
,9
]}

Celum, Connie ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA 98104 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA

[4] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[5] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[6] Univ Witwatersrand, Sch Clin Med, Wits Inst Reprod Hlth & HIV, Johannesburg, South Africa

[7] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[8] Univ Washington, Dept Lab Med, Seattle, WA 98104 USA

[9] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

来源：

SEXUALLY TRANSMITTED DISEASES | 2012年 / 39卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ORAL ACYCLOVIR; DOUBLE-BLIND; SUPPRESSION; MEN; VALACYCLOVIR; ACQUISITION; INFECTION; EFFICACY; IMPACT; RNA;

D O I：

10.1097/OLQ.0b013e31823b50c6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).

引用

页码：21 / 24

页数：4

共 43 条

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[43] Daily oral tenofovir and emtricitabine-tenofovir pre-exposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial (vol 161, pg 11, 2014)
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