Mechanism of Shigella entry into epithelial cells

被引：1
|
作者：
Van Nhieu, GT [1 ]
Sansonetti, PJ [1 ]
机构：
[1] Inst Pasteur, INSERM, U389, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France
来源：
CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Shigella, the causative agent of bacillary dysentery, invades epithelial cells by reorganizing the cell cytoskeleton during bacterial entry. This entry process requires the Shigella Ipa proteins that are secreted by a type III secretion apparatus and that act in concert to fine tune cell responses. Actin polymerization at the site of entry is dependent on the IpaB and IpaC proteins, whereas IpaA further modulates cytoskeletal rearrangements by binding to vinculin.
引用
收藏
页码：51 / 55
页数：5
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