Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound

被引：374

作者：

Baka, Edit ^{[1
]}

Comer, John E. A. ^{[2
]}

Takacs-Novak, Krisztina ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest Hogyes, Hungary

[2] Sirius Analyt Ltd, E Sussex RH18 5DW, England

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 46卷 / 02期

关键词：

solubility; saturation shake-flask method; hydrochlorothiazide;

D O I：

10.1016/j.jpba.2007.10.030

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The experimental conditions that affect equilibrium solubility values measured by the classical saturation shake-flask method have been examined, using hydrochlorothiazide as a model compound. Modifications in temperature, sedimentation time, composition of aqueous buffer and the technique of separation of solid and liquid phases were all found to influence the equilibrium solubility results strongly. However, variations in the amount of solid excess and stirring time were found to have less influence. In the light of these observations, a new, shorter protocol has been developed for measurements of equilibrium solubility, together with recommendations for good analytical practice. The equilibrium solubilities of five other drugs were measured to verify the new protocol. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：335 / 341

页数：7

共 29 条

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