Study Design: This is a case report. Introduction: Persons with rheumatoid arthritis frequently use assistive devices as a compensatory strategy to enhance occupational performance when client factors such as hand weakness, pain, and/or limited range of motion interfere with activity performance. Computer-aided design software and 3D printers are increasingly being used to design and make assistive devices. Purpose of the Study: This case report describes a client-centered approach in the selection, three-dimensional (3D) printing, and evaluation of outcomes for three assistive devices to enhance occupational performance in a subject with rheumatoid arthritis. Methods: Outcome measures used in this study included the Patient-Specific Functional Scale, Numeric Pain Rating Scale, and Quebec User Evaluation of Satisfaction with Assistive Technology V2.0. Activity analysis along with the subject input informed a client-centered approach in the selection, color, and design modifications of 3D printed assistive devices made for the study. Results: The subject reported decreased pain, improved occupational performance, and satisfaction with use of 3D printed assistive devices to open plastic beverage bottles, unlock/lock doors, and write. Discussion: 3D printing offers therapists a means to design and make assistive devices that can be cost-effective, customizable, and client-centered. Conclusion: Assistive devices made with 3D printing resulted in positive outcomes in a subject with rheumatoid arthritis. (C) 2020 Hanley & Belfus, an imprint of Elsevier Inc. All rights reserved.