Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis

被引：27
|
作者：
Lin, CE [1 ]
Liao, WS [1 ]
Chen, KH [1 ]
Lin, WY [1 ]
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
来源：
ELECTROPHORESIS | 2003年 / 24卷 / 18期
关键词：
capillary zone electrophoresis; phenothiazines; pK(a) determination;
D O I：
10.1002/elps.200305559
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The influence of buffer pH on the electrophoretic behavior of 13 structurally related phenothiazines and determination of pK(a) values by capillary zone electrophoresis (CZE) were investigated. The results indicate that phenothiazines with a piperazine substituent behave quite differently from those with substituents having an aliphatic side chain or a piperidine moiety over the pH range studied. To separate these phenothiazines, it is preferable to select buffer pH in the range of 2.5-3.5. The pK(a) values of phenothiazines with three different types of substituents attached at the 10-position of the phenothiazine ring were determined. The determination of pK(a) values of phenothiazines allows us to rationalize the influence of buffer pH on the migration behavior of these compounds in CZE.
引用
收藏
页码：3154 / 3159
页数：6
相关论文
共 50 条
  • [31] Enantioseparation of phenothiazines in capillary zone electrophoresis using cyclodextrins as chiral selectors
    Lin, CE
    Chen, KH
    JOURNAL OF CHROMATOGRAPHY A, 2001, 930 (1-2) : 155 - 163
  • [32] Effects of structural modification of the daunosamine moiety of anthracycline antibiotics on pKa values determined by capillary zone electrophoresis
    Matyjaszczyk, Karolina
    Kolonko, Marta
    Gonciarz-Dytman, Anna
    Oszczapowicz, Irena
    Lukawska, Malgorzata
    Jawien, Wojciech
    Chlopicki, Stefan
    Walczak, Maria
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 1060 : 44 - 52
  • [33] Determination of pKa values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis
    Wang, Jian-Ling
    Xu, Xue-Jiao
    Chen, Dong-Ying
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 88 : 22 - 26
  • [34] Determination of thermodynamic pKa values of pharmaceuticals from five different groups using capillary electrophoresis
    Zrncic, Mirta
    Babic, Sandra
    Pavlovic, Dragana Mutavdzic
    JOURNAL OF SEPARATION SCIENCE, 2015, 38 (07) : 1232 - 1239
  • [35] Determination of Pka Values of Antidiabetic Drugs from Mobility Data and Pharmaceutical Analysis by Capillary Electrophoresis
    Sanli, Senem
    Sardogan, Seyfi
    Ozdemir, Ayse
    Atalay, Baris
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2022, 44 (04): : 366 - 373
  • [36] Determination and modeling of peptide pKa by capillary zone electrophoresis (vol 78, pg 5394, 2006)
    Plasson, Raphael
    Cottet, Herve
    ANALYTICAL CHEMISTRY, 2007, 79 (07) : 3020 - 3020
  • [37] Determination of acarbose by capillary zone electrophoresis
    Lachmann, B.
    Noe, C. R.
    PHARMAZIE, 2013, 68 (07): : 531 - 533
  • [38] Influence of pH and pKa values on electrophoretic behaviour of quinolones in aqueous and hydro-organic media
    Barrón, D
    Jiménez-Lozano, E
    Irles, A
    Barbosa, J
    JOURNAL OF CHROMATOGRAPHY A, 2000, 871 (1-2) : 381 - 389
  • [39] DETERMINATION OF VARENICLINE BY CAPILLARY ZONE ELECTROPHORESIS
    Alhazmi, Hassan A.
    Makeen, Hafiz A.
    El Deeb, Sami
    DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2013, 8 (01) : 295 - 300
  • [40] CAPILLARY ZONE ELECTROPHORESIS IN DETERMINATION OF MICROORGANISMS
    Klodzinska, Ewa
    Tanase, Stefania
    Tomescu, Andra Alina
    Moga, Marius
    Buszewski, Boguslaw
    REVUE ROUMAINE DE CHIMIE, 2010, 55 (06) : 283 - 288
12345