Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

被引：16
|
作者：
Huang, CC [1 ]
Lin, CH [1 ]
Gean, PW [1 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 701, Taiwan
来源：
NEUROSCIENCE LETTERS | 1998年 / 253卷 / 01期
关键词：
isoproterenol; N-methyl-D-aspartate receptor; amygdala; forskolin; protein kinase A;
D O I：
10.1016/S0304-3940(98)00571-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.
引用
收藏
页码：9 / 12
页数：4
相关论文
共 50 条
  • [11] PREGNENOLONE SULFATE POTENTIATION OF N-METHYL-D-ASPARTATE RECEPTOR CHANNELS IN HIPPOCAMPAL-NEURONS
    BOWLBY, MR
    MOLECULAR PHARMACOLOGY, 1993, 43 (05) : 813 - 819
  • [12] Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons
    Moriguchi, S
    Zhao, XL
    Marszalec, W
    Yeh, JZ
    Narahashi, T
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (01): : 125 - 135
  • [13] A COMPARISON OF THE EFFECTS OF N-METHYL-D-ASPARTATE AND QUINOLINATE ON CENTRAL NEURONS OF THE RAT
    MCLENNAN, H
    NEUROSCIENCE LETTERS, 1984, 46 (02) : 157 - 160
  • [14] TEMPERATURE DEPENDENCE OF N-METHYL-D-ASPARTATE RECEPTOR CHANNELS AND N-METHYL-D-ASPARTATE RECEPTOR EXCITATORY POSTSYNAPTIC CURRENTS
    Korinek, M.
    Sedlacek, M.
    Cais, O.
    Dittert, I.
    Vyklicky, L., Jr.
    NEUROSCIENCE, 2010, 165 (03) : 736 - 748
  • [15] N-METHYL-D-ASPARTATE ACUTELY INCREASES PROENKEPHALIN MESSENGER-RNA IN THE RAT STRIATUM
    BECKSTEAD, RM
    SYNAPSE, 1995, 21 (04) : 342 - 347
  • [16] TACHYKININS POTENTIATE N-METHYL-D-ASPARTATE RESPONSES IN ACUTELY ISOLATED NEURONS FROM THE DORSAL HORN
    RUSIN, KI
    BLEAKMAN, D
    CHARD, PS
    RANDIC, M
    MILLER, RJ
    JOURNAL OF NEUROCHEMISTRY, 1993, 60 (03) : 952 - 960
  • [17] Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits
    Zheng, X
    Zhang, L
    Wang, AP
    Bennett, MVL
    Zukin, RS
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 15262 - 15267
  • [18] Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons
    Moriguchi, S
    Marszalec, W
    Zhao, XL
    Yeh, JZ
    Narahashi, T
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (03): : 933 - 942
  • [19] Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons
    Shirakawa, H
    Katsuki, H
    Kume, T
    Kaneko, S
    Ito, J
    Akaike, A
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 454 (2-3) : 165 - 175
  • [20] GLYCINE ACTION ON N-METHYL-D-ASPARTATE RECEPTORS IN RAT HIPPOCAMPAL-NEURONS
    CHIZHMAKOV, IV
    KISKIN, NI
    KRISHTAL, OA
    TSYNDRENKO, AY
    NEUROSCIENCE LETTERS, 1989, 99 (1-2) : 131 - 136
12345