Poly(ethylene glycol)-based polymer carrier of doxorubicin degradable by both enzymatic and chemical hydrolyses

被引：10
|
作者：
Pechar, M [1 ]
Braunová, A [1 ]
Ulbrich, K [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2005年 / 70卷 / 03期
关键词：
drug delivery systems; cancer therapy; doxorubicin; poly(ethylene glycol); peptide synthesis; polymer-supported drugs; antineoplastics; cytostatics; biodegradable polymers;
D O I：
10.1135/cccc20050327
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis and characterization of a water-soluble biodegradable multiblock polyurethane based on poly(ethylene glycol) blocks interconnected by a pentapeptide derivative N, N'-bis(aspartylprolyl)lysine is described. The pentapeptide linkages are susceptible both to chemical hydrolysis in neutral and mild acid medium (pH 5) and to enzymatic degradation by lysosomal enzyme cathepsin B. Anti-cancer drug doxorubicin was attached to a hydrazide derivative of the polymer via a hydrolytically labile hydrazone bond. Both the pH-triggered hydrolytic release of the drug and the degradation of the polymer carrier by enzymatic and chemical hydrolysis were studied using liquid chromatography.
引用
收藏
页码：327 / 338
页数：12
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