Vaccination with attenuated simian immunodeficiency virus by DNA inoculation

被引：28
|
作者：
Kent, SJ [1 ]
Dale, CJ
Preiss, S
Mills, J
Campagna, D
Purcell, DFJ
机构：
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[2] Macfarlane Burnet Ctr Med Res, Fairfield, Vic 3078, Australia
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 23期
关键词：
D O I：
10.1128/JVI.75.23.11930-11934.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIVmac239) DNA or SIVmac239 DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIVmac239 DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIVmac251 challenge.
引用
收藏
页码：11930 / 11934
页数：5
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