Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

被引：48
|
作者：
Zhou, Ling-ling [1 ,2 ]
Wei, Wei [1 ]
Si, Jun-feng [3 ]
Yuan, Dong-ping [2 ]
机构：
[1] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immunopharmacol, Educ Minist China, Hefei 230032, Peoples R China
[2] Nanjing Univ Tradit Chinese Med, Dept Pharmacol, Jiangsu Prov Key Lab Pharmacol & Safety Evaluat M, Nanjing 210029, Peoples R China
[3] Nanjing Univ, Inst Biomed Elect Engn, Nanjing 210093, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2010年 / 2010卷
关键词：
IMMUNE-RESPONSES; ERYTHEMATOSUS; ANTIBODIES; INTERLEUKIN-6; CELLS; MECHANISMS; GROWTH; ALPHA; GAMMA;
D O I：
10.1155/2010/951210
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.
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页数：7
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