Cortisol and post-traumatic stress disorder

被引：0

作者：

Garcia, Magalie ^{[1
,2
]}

Bruno, Nicolas ^{[3
]}

Grunenwald, Solange ^{[4
]}

Bui, Eric ^{[1
,2
,5
,6
]}

Birmes, Philippe ^{[1
,2
]}

机构：

[1] Univ Toulouse 3, F-31062 Toulouse, France

[2] Hop Casselardit, Lab Stress Traumat LST EA 4560, Toulouse, France

[3] CHU St Antoine, Psychiat Serv, Paris, France

[4] CHU Toulouse, Serv Endocrinol Malad Metabol & Nutr, Toulouse, France

[5] Massachusetts Gen Hosp, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

来源：

CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2012年 / 16卷 / 1-2期

关键词：

Cortisol; Post-traumatic stress disorder; Hypothalamic-pituitary-adrenal axis; Glucocorticoid receptor; FKPB5; gene;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cortisol regulation abnormalities are noticed in post-traumatic stress disorder (PTSD). The basal cortisol level is often lowered. The reactivity of the hypothalamic-pituitary-adrenal (HPA) tests stimulation is increased. Exposure to a traumatic event may have more effects than PTSD itself on the HPA axis. At molecular level, some cartisol-related genes are more expressed in case of PTSD. In functional brain imaging, administration of glucocorticoids normalizes the abnormal activation of some areas previously modified by PTSD. Molecules targeting glucocorticoids receptors are used experimentally in animals, with encouraging results.

引用

页码：26 / 30

页数：5

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