Ultrasound Contrast Agent Microbubble Modeling with Bubbles Interaction

We present a new model including the interaction among bubbles to describe the dynamic behavior of ultrasound contrast agent (UCA) microbubble. In fact, the secondary Bjerknes force that indicates the mutual interaction between gas bubbles has already been discovered by Bjerknes in the acoustic field. Thus, it is necessary to take the bubble interaction into account when studying the dynamic behavior of microbubble. In our work, we propose a new model-" model with bubbles interaction" (MBI)-including the interaction of bubbles to characterize the behavior of bubbles. As a consequence, we find that the interaction of bubbles can influence the "compressonly" behavior to some extent. To verify our discovery, simulation results of the proposed model were compared with Morgan, Hoff, and Doinikov model. In the end, we find that the "compress-only" behavior is more obvious when the concentration of the UCA increases. Proposed MBI model can fit the phenomenon very well.